George Poste, David P. Carbone, David R. Parkinson, et al. Clin Cancer Res 2012;18:1515-1523. Published online March 14, 2012. Abstract: Molecular diagnostics are becoming increasingly important in clinical research to stratify or identify molecularly profiled patient cohorts for targeted therapies, to modify the dose of a therapeutic, and to assess early response to therapy or monitor patients. Molecular diagnostics can also be used to identify the pharmacogenetic risk of adverse drug reactions.